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pentobarbital will lessen the level or effect of lefamulin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Stay clear of coadministration of lefamulin with potent or average CYP3A inducers Until the advantage outweighs pitfalls. Observe for lowered efficacy.pentobarbital will lessen the level or result of al